ALPP

Across TCGA patient cohorts, ALPP mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALPP-associated genes across cancer lineages are ERK2, MEK1, and p27_pT198. Each is linked with ALPP in more than 2 cancer types. Because this analysis shows association rather than direction, both ALPP-to-partner and partner-to-ALPP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by ALPP-low versus ALPP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALPP→partner) and Y-score (partner→ALPP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.261	+2.700	.002	.006	3	3
UCEC	MEK1 →	+0.373	+3.169	.023	.019	3	2
UCEC	p27_pT198 →	+0.124	+2.000	.010	.032	3	2
UCEC	4E-BP1 →	+0.416	+2.351	<.001	.018	3	2
LUSC	ETS-1 →	+0.183	+2.816	.023	.036	3	1
SKCM	YB-1 →	-0.301	-2.987	.004	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

ERK2 by ALPP expression — UCEC

Explore this box plot interactively →