ALPP

Across TCGA cell cohorts, ALPP RNA expression is significantly associated with the go_rna of many other GO terms, with 3,110 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ALPP-associated GO terms across cancer lineages are Protein localization to cell-cell junction, Negative regulation of stress fiber assembly, and Regulation of cardiac muscle tissue development. Each is linked with ALPP in more than 9 cancer types. Because this analysis shows association rather than direction, both ALPP-to-partner and partner-to-ALPP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to cell-cell junction grouped by ALPP-low versus ALPP-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ALPP→partner) and Y-score (partner→ALPP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Protein localization to cell-cell junction →	+0.130	+3.393	<.001	<.001	3	10
OESOPHAGUS	Negative regulation of stress fiber assembly →	+0.149	+3.990	.004	.003	2	10
STOMACH	Regulation of cardiac muscle tissue development →	+1.501	+4.063	<.001	.001	3	9
STOMACH	mRNA transport →	+0.120	+4.020	.002	.004	3	9
BREAST	Positive regulation of purine nucleotide biosynthetic process →	+0.127	+2.341	.001	.003	3	9
BREAST	Positive regulation of ATP biosynthetic process →	+0.125	+2.341	.001	.003	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,110 associations by consensus.

Protein localization to cell-cell junction by ALPP expression — STOMACH

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