ALPP

Across TCGA cell cohorts, ALPP mutation is significantly associated with the RNA expression of many other genes, with 188 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ALPP-associated genes across cancer lineages are FAM205A, H2BC1, and H2AC1. Each is linked with ALPP in more than 1 cancer types. Because this analysis shows association rather than direction, both ALPP-to-partner and partner-to-ALPP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM205A grouped by ALPP-low versus ALPP-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALPP→partner) and Y-score (partner→ALPP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM205A →	+0.015	+3.029	<.001	.002	3	2
SOFT_TISSUE	H2BC1 →	+0.325	+4.977	<.001	.002	3	1
SOFT_TISSUE	H2AC1 →	+0.145	+4.977	<.001	.002	3	1
LUNG_NSCLC_LUSC	KRTAP13-2 →	+0.229	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	ARMH2 →	+0.020	+4.643	<.001	.008	3	1
BLOOD_Leukemia	EPPIN →	+0.005	+4.507	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 188 associations by consensus.

FAM205A by ALPP expression — LARGE_INTESTINE

Explore this box plot interactively →