ALPK3

Across TCGA patient cohorts, ALPK3 protein abundance is significantly associated with the RNA expression of many other genes, with 3,431 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALPK3-associated genes across cancer lineages are TMPRSS3, BDNF, and ASH1L-IT1. Each is linked with ALPK3 in more than 2 cancer types. Because this analysis shows association rather than direction, both ALPK3-to-partner and partner-to-ALPK3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ALPK3 versus TMPRSS3 in LSCC, with a Pearson correlation of 0.58.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALPK3→partner) and Y-score (partner→ALPK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TMPRSS3 →	+1.805	+1.456	.008	.002	3	2
LSCC	BDNF →	-1.035	-0.963	.001	.009	3	2
UCEC	ASH1L-IT1 →	-1.315	-0.542	.003	.006	3	2
UCEC	RPL19P11 →	-0.514	-0.629	.003	<.001	3	2
HNSC	LINC00504 →	-0.828	-0.596	.001	.002	3	2
UCEC	CENATAC-DT →	-0.532	-0.646	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,431 associations by consensus.

ALPK3 vs TMPRSS3 — LSCC

Explore this scatter interactively →