ALPK3

Across TCGA pan-cancer cohorts, ALPK3 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated ALPK3 data layer compared with 10 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher ALPK3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ALPK3 expression acts as an unfavorable survival marker, although some lineages such as KIRC and KIRP show a favorable association.

UVM, LIHC, and LGG are the cancer types where ALPK3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.412	0.800	.001	95	view →
LIHC	OS	Quartile	All	0.666	0.907	<.001	59	view →
LGG	OS	Median	All	0.748	0.869	<.001	53	view →
MESO	OS	Tertile	All	0.269	0.536	.001	48	view →
KIRC	DFS	Median	IV	0.631	0.281	.002	45	view →
KIRP	DFS	Tertile	All	0.974	0.820	<.001	37	view →
PAAD	DFS	Tertile	All	0.438	0.240	.002	21	view →
UCS	DFS	Tertile	IV	0.978	0.488	.024	20	view →
UCEC	OS	Tertile	III,IV	0.929	0.751	.008	18	view →
OV	DFS	Tertile	II,III,IV	0.477	0.587	.007	16	view →
HNSC	OS	Median	II,III,IV	0.276	0.488	.002	14	view →
CHOL	DFS	Tertile	All	0.109	0.640	.009	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

ALPK3–UVM (DFS)

Open the UVM breakdown →