ALPK3

Across TCGA patient cohorts, ALPK3 mutation is significantly associated with the RNA expression of many other genes, with 4,497 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALPK3-associated genes across cancer lineages are CENPU, BLCAP, and ZNF311. Each is linked with ALPK3 in more than 3 cancer types. Because this analysis shows association rather than direction, both ALPK3-to-partner and partner-to-ALPK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPU grouped by ALPK3-low versus ALPK3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALPK3→partner) and Y-score (partner→ALPK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CENPU →	+0.754	+3.584	<.001	.002	3	4
COAD	BLCAP →	-0.509	-2.906	<.001	.001	3	4
UCEC	ZNF311 →	-0.486	-2.553	<.001	<.001	3	4
COAD	PTMAP4 →	+1.425	+2.933	<.001	<.001	3	4
COAD	TATDN3 →	+0.415	+3.479	.002	.002	3	4
SKCM	CCNB1 →	+0.396	+1.328	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,497 associations by consensus.

CENPU by ALPK3 expression — COAD

Explore this box plot interactively →