ALPK3

Across TCGA patient cohorts, ALPK3 mutation is significantly associated with the total protein of many other genes, with 71 significant associations in total. COAD shows the largest number of these associations.

The most reproducible ALPK3-associated genes across cancer lineages are ASNS, MYH11, and Caveolin-1. Each is linked with ALPK3 in more than 3 cancer types. Because this analysis shows association rather than direction, both ALPK3-to-partner and partner-to-ALPK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by ALPK3-low versus ALPK3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALPK3→partner) and Y-score (partner→ALPK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.402	+2.815	.009	.001	3	4
STAD	MYH11 →	-1.525	-3.000	.047	.036	3	3
CESC	Caveolin-1 →	-0.685	-3.000	.041	.033	3	3
SKCM	Ku80 →	+0.273	+1.736	.004	.006	3	3
COAD	eIF4E →	+0.186	+3.169	.008	.017	3	3
COAD	PCNA →	+0.201	+1.593	.039	.043	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

ASNS by ALPK3 expression — COAD

Explore this box plot interactively →