ALPK3

Across TCGA cell cohorts, ALPK3 mutation is significantly associated with the RNA expression of many other genes, with 700 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ALPK3-associated genes across cancer lineages are OR13D1, OOSP3, and TBC1D28. Each is linked with ALPK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALPK3-to-partner and partner-to-ALPK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR13D1 grouped by ALPK3-low versus ALPK3-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALPK3→partner) and Y-score (partner→ALPK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OR13D1 →	+0.026	+4.217	<.001	.005	3	2
SOFT_TISSUE	OOSP3 →	+0.072	+3.736	<.001	.008	3	2
CNS	TBC1D28 →	+0.047	+2.619	.005	.009	3	2
LARGE_INTESTINE	CTSZ →	-0.844	-3.584	.006	<.001	3	2
LARGE_INTESTINE	ERI1 →	+0.577	+3.321	.002	.003	3	2
LARGE_INTESTINE	TTC33 →	+0.744	+2.949	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 700 associations by consensus.

OR13D1 by ALPK3 expression — URINARY_TRACT

Explore this box plot interactively →