ALPI

Across TCGA patient cohorts, ALPI mutation is significantly associated with the RNA expression of many other genes, with 1,566 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALPI-associated genes across cancer lineages are GINS2, PSMC3IP, and RNFT2. Each is linked with ALPI in more than 2 cancer types. Because this analysis shows association rather than direction, both ALPI-to-partner and partner-to-ALPI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GINS2 grouped by ALPI-low versus ALPI-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALPI→partner) and Y-score (partner→ALPI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GINS2 →	+0.743	+2.705	.001	<.001	3	3
COAD	PSMC3IP →	+0.579	+3.486	<.001	.002	3	3
UCEC	RNFT2 →	+0.470	+2.606	.007	.005	3	3
BLCA	RNU6-227P →	+0.207	+4.618	<.001	.005	3	3
UCEC	EME1 →	+0.533	+2.180	.003	.002	3	3
UCEC	ZMYND19 →	+0.490	+3.923	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,566 associations by consensus.

GINS2 by ALPI expression — UCEC

Explore this box plot interactively →