ALPI

Across TCGA pan-cancer cohorts, ALPI RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated ALPI data layer compared with 7 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ALPI RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ALPI expression acts as an unfavorable survival marker, although some lineages such as KIRC and MESO show a favorable association.

LUAD, ACC, and DLBC are the cancer types where ALPI RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	III,IV	0.476	0.725	<.001	107	view →
ACC	OS	Quartile	III,IV	0.425	0.839	<.001	41	view →
DLBC	OS	Tertile	All	0.546	0.875	.014	36	view →
PAAD	OS	Median	All	0.382	0.584	.008	26	view →
PCPG	DFS	Tertile	All	0.072	0.875	<.001	21	view →
KIRC	DFS	Quartile	III,IV	0.653	0.377	.022	19	view →
KICH	OS	Tertile	II,III,IV	0.814	0.954	.010	18	view →
SCLC	DFS	Tertile	All	0.274	0.815	.013	18	view →
TGCT	DFS	Tertile	All	0.678	0.900	.006	12	view →
LGG	OS	Tertile	All	0.798	0.922	.021	12	view →
MESO	DFS	Tertile	III,IV	0.795	0.253	.028	12	view →
THYM	DFS	Tertile	III,IV	0.511	0.925	.043	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

ALPI–LUAD (OS)

Open the LUAD breakdown →