ALPI

Across TCGA patient cohorts, ALPI mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALPI-associated genes across cancer lineages are eIF4E, Notch1, and Annexin-1. Each is linked with ALPI in more than 1 cancer types. Because this analysis shows association rather than direction, both ALPI-to-partner and partner-to-ALPI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ALPI-low versus ALPI-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALPI→partner) and Y-score (partner→ALPI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.279	+3.472	.001	.002	3	2
UCEC	Notch1 →	+0.142	+2.469	.014	.010	3	2
UCEC	Annexin-1 →	+0.670	+3.479	.002	.002	3	2
UCEC	Shc_pY317 →	-0.156	-2.321	.012	.006	3	2
UCEC	ASNS →	+0.447	+1.807	.002	.027	3	2
UCEC	ATM →	-0.509	-2.986	.006	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

eIF4E by ALPI expression — UCEC

Explore this box plot interactively →