ALPI

Across TCGA cell cohorts, ALPI mutation is significantly associated with the RNA expression of many other genes, with 38 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible ALPI-associated genes across cancer lineages are HSD11B1, CGB3, and FGD2. Each is linked with ALPI in more than 1 cancer types. Because this analysis shows association rather than direction, both ALPI-to-partner and partner-to-ALPI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSD11B1 grouped by ALPI-low versus ALPI-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALPI→partner) and Y-score (partner→ALPI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	HSD11B1 →	+0.623	+3.906	.001	.002	3	2
SKIN	CGB3 →	+0.133	+2.657	.005	.007	3	1
SKIN	FGD2 →	+0.196	+3.736	.001	.003	3	1
SKIN	FOXI1 →	+0.029	+3.505	.005	<.001	3	1
SKIN	MUC17 →	+0.022	+2.657	.001	.007	3	1
SKIN	PRF1 →	+0.090	+3.374	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

HSD11B1 by ALPI expression — LUNG_SCLC

Explore this box plot interactively →