ALPG

Across TCGA pan-cancer cohorts, ALPG Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ALPG data layer compared with 22 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher ALPG Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ALPG expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

THYM, BLCA, and LIHC are the cancer types where ALPG Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
BLCA	OS	Median	All	0.228	0.722	<.001	36	view →
LIHC	OS	Median	All	0.166	0.786	<.001	12	view →
LGG	OS	Median	All	0.332	0.830	.009	3	view →
UCEC	DFS	Median	All	1.000	0.631	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ALPG–THYM (OS)

Open the THYM breakdown →