ALPG

Across TCGA patient cohorts, ALPG mutation is significantly associated with the RNA expression of many other genes, with 529 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALPG-associated genes across cancer lineages are COTL1P2, OR2S2, and OR4A13P. Each is linked with ALPG in more than 2 cancer types. Because this analysis shows association rather than direction, both ALPG-to-partner and partner-to-ALPG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COTL1P2 grouped by ALPG-low versus ALPG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALPG→partner) and Y-score (partner→ALPG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	COTL1P2 →	+0.252	+1.874	<.001	.008	3	3
GBM	OR2S2 →	+0.061	+4.273	<.001	.008	3	2
HNSC	OR4A13P →	+0.069	+4.141	<.001	.003	3	2
HNSC	RNU6-317P →	+0.204	+4.754	<.001	.005	3	2
HNSC	RNU6-1250P →	+0.201	+4.327	<.001	.009	3	2
HNSC	RNA5SP198 →	+0.186	+5.772	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 529 associations by consensus.

COTL1P2 by ALPG expression — UCEC

Explore this box plot interactively →