ALPG

Across TCGA patient cohorts, ALPG mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALPG-associated genes across cancer lineages are MEK1, p27_pT198, and C-Raf. Each is linked with ALPG in more than 1 cancer types. Because this analysis shows association rather than direction, both ALPG-to-partner and partner-to-ALPG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ALPG-low versus ALPG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALPG→partner) and Y-score (partner→ALPG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.337	+3.169	.041	.019	3	2
UCEC	p27_pT198 →	+0.095	+2.000	.048	.032	3	2
UCEC	C-Raf →	+0.180	+2.000	.005	.032	3	2
SKCM	PREX1 →	-0.377	-3.152	.034	.019	3	1
SKCM	c-Met_pY1235 →	+0.105	+3.012	.022	.018	3	1
UCEC	JNK_pT183_Y185 →	-0.200	-1.986	.008	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

MEK1 by ALPG expression — UCEC

Explore this box plot interactively →