ALPG

Across TCGA cell cohorts, ALPG RNA expression is significantly associated with the go_rna of many other GO terms, with 1,508 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ALPG-associated GO terms across cancer lineages are Adenylate cyclase-modulating G protein-coupled receptor signaling pathway, Cellular response to indole-3-methanol, and Rho protein signal transduction. Each is linked with ALPG in more than 6 cancer types. Because this analysis shows association rather than direction, both ALPG-to-partner and partner-to-ALPG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Adenylate cyclase-modulating G protein-coupled receptor signaling pathway grouped by ALPG-low versus ALPG-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ALPG→partner) and Y-score (partner→ALPG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway →	-0.051	-2.796	.001	<.001	3	7
LUNG_NSCLC_LUAD	Cellular response to indole-3-methanol →	+0.166	+1.093	<.001	<.001	3	6
LARGE_INTESTINE	Rho protein signal transduction →	+0.102	+1.652	<.001	.008	3	6
STOMACH	T cell mediated cytotoxicity →	+0.177	+1.801	.001	.002	3	6
PANCREAS	Regulation of muscle filament sliding →	+1.223	+2.438	.003	.001	2	7
STOMACH	Negative regulation of RNA splicing →	+0.103	+2.178	<.001	.007	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,508 associations by consensus.

Adenylate cyclase-modulating G protein-coupled receptor signaling pathway by ALPG expression — STOMACH

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