ALOXE3

Across TCGA cell cohorts, ALOXE3 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible ALOXE3-associated genes across cancer lineages are COX4I2, CABP5, and SLC36A3. Each is linked with ALOXE3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALOXE3-to-partner and partner-to-ALOXE3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COX4I2 grouped by ALOXE3-low versus ALOXE3-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALOXE3→partner) and Y-score (partner→ALOXE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	COX4I2 →	+0.095	+5.228	<.001	.005	3	2
KIDNEY	CABP5 →	+0.013	+5.000	<.001	.005	3	1
KIDNEY	SLC36A3 →	+0.006	+5.000	<.001	.005	3	1
KIDNEY	OR2AK2 →	+0.020	+5.000	<.001	.005	3	1
LUNG_SCLC	OR5H2 →	+0.037	+4.643	<.001	.004	3	1
LUNG_SCLC	ASIC5 →	+0.073	+4.269	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

COX4I2 by ALOXE3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →