ALOX5

Across TCGA pan-cancer cohorts, ALOX5 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ALOX5 data layer compared with 26 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ALOX5 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ALOX5 expression acts as an unfavorable survival marker.

COAD, HNSC, and LUAD are the cancer types where ALOX5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.878	1.000	.017	30	view →
HNSC	DFS	Median	All	0.907	0.994	.004	10	view →
LUAD	DFS	Quartile	III,IV	0.389	0.852	.016	9	view →
LSCC	DFS	Median	II,III,IV	0.552	0.826	.024	6	view →
CCRCC	OS	Median	III,IV	0.724	0.896	.023	4	view →
PDAC	OS	Median	III,IV	0.621	0.871	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ALOX5–COAD (DFS)

Open the COAD breakdown →