ALOX5

Across TCGA pan-cancer cohorts, ALOX5 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of ALOX5’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ALOX5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ALOX5 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

KIRC, THCA, and KIRP are the cancer types where ALOX5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ALOX5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+2.561	<.001	12	view →
THCA	All	IV	+4.942	<.001	11	view →
KIRP	Male	II,III,IV	+2.920	<.001	11	view →
LUSC	Male	II,III,IV	−2.856	<.001	9	view →
LUAD	Female	III,IV	−2.016	<.001	9	view →
CHOL	All	All	+3.151	<.001	5	view →
STAD	All	All	+0.954	<.001	5	view →
KICH	All	II,III,IV	−1.181	.003	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

ALOX5–KIRC

Open the KIRC breakdown →