ALOX5

Across TCGA patient cohorts, ALOX5 protein abundance is significantly associated with the RNA expression of many other genes, with 20,672 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ALOX5-associated genes across cancer lineages are CYTH4, SIRPB1, and TLR8. Each is linked with ALOX5 in more than 9 cancer types. Because this analysis shows association rather than direction, both ALOX5-to-partner and partner-to-ALOX5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ALOX5 versus CYTH4 in GBM, with a Pearson correlation of 0.82.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALOX5→partner) and Y-score (partner→ALOX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CYTH4 →	+1.215	+0.890	<.001	<.001	3	10
BRCA	SIRPB1 →	+0.651	+0.421	<.001	<.001	3	10
HNSC	TLR8 →	+1.281	+0.551	<.001	<.001	3	10
GBM	IL21R →	+1.462	+0.830	<.001	<.001	3	10
GBM	LILRB1 →	+1.120	+0.953	<.001	<.001	3	10
GBM	RASAL3 →	+0.862	+0.813	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,672 associations by consensus.

ALOX5 vs CYTH4 — GBM

Explore this scatter interactively →