ALOX5

Across TCGA patient cohorts, ALOX5 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALOX5-associated genes across cancer lineages are ATM, eIF4E, and INPP4B. Each is linked with ALOX5 in more than 2 cancer types. Because this analysis shows association rather than direction, both ALOX5-to-partner and partner-to-ALOX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ALOX5-low versus ALOX5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALOX5→partner) and Y-score (partner→ALOX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.434	-1.906	.007	.015	3	3
COAD	eIF4E →	+0.324	+2.820	<.001	.035	3	2
UCEC	INPP4B →	-0.345	-2.700	.002	.005	3	2
UCEC	JNK_pT183_Y185 →	-0.179	-2.321	.003	.005	3	2
UCEC	JNK2 →	+0.171	+1.594	.016	.042	3	2
UCEC	mTOR_pS2448 →	-0.114	-1.980	.034	.030	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

ATM by ALOX5 expression — UCEC

Explore this box plot interactively →