ALOX5

Across TCGA cell cohorts, ALOX5 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,235 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ALOX5-associated GO terms across cancer lineages are Lipoxin biosynthetic process, Lipoxygenase pathway, and Macropinocytosis. Each is linked with ALOX5 in more than 11 cancer types. Because this analysis shows association rather than direction, both ALOX5-to-partner and partner-to-ALOX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lipoxin biosynthetic process grouped by ALOX5-low versus ALOX5-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ALOX5→partner) and Y-score (partner→ALOX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Lipoxin biosynthetic process →	+2.031	+3.844	<.001	<.001	3	12
OESOPHAGUS	Lipoxygenase pathway →	-0.312	-1.693	<.001	.008	3	10
BLOOD_Leukemia	Macropinocytosis →	+0.110	+1.193	.001	.002	3	10
BREAST	Negative regulation of myeloid leukocyte mediated immunity →	+1.920	+2.026	<.001	<.001	3	9
BREAST	Negative regulation of mast cell degranulation →	+1.689	+2.187	<.001	<.001	3	9
PANCREAS	Glycerophospholipid metabolic process →	+0.051	+2.899	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,235 associations by consensus.

Lipoxin biosynthetic process by ALOX5 expression — URINARY_TRACT

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