ALOX5

Across TCGA cell cohorts, ALOX5 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ALOX5-associated genes across cancer lineages are C7orf33, SLCO6A1, and VENTX. Each is linked with ALOX5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALOX5-to-partner and partner-to-ALOX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C7orf33 grouped by ALOX5-low versus ALOX5-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALOX5→partner) and Y-score (partner→ALOX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	C7orf33 →	+0.049	+4.990	<.001	.001	3	2
PANCREAS	SLCO6A1 →	+0.191	+4.491	<.001	.003	3	1
LUNG_NSCLC_LUAD	VENTX →	+0.243	+3.700	<.001	.009	3	1
LUNG_NSCLC_LUAD	DCSTAMP →	+0.090	+3.734	<.001	.006	3	1
LUNG_NSCLC_LUAD	OR51Q1 →	+0.110	+3.866	.002	.006	3	1
LUNG_NSCLC_LUAD	SIGLEC7 →	+0.037	+4.215	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

C7orf33 by ALOX5 expression — OVARY

Explore this box plot interactively →