ALOX5

Across TCGA cell cohorts, ALOX5 mutation is significantly associated with the mutation status of many other genes, with 4,143 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ALOX5-associated genes across cancer lineages are CDH24, FHOD3, and APBA1. Each is linked with ALOX5 in more than 4 cancer types. Because this analysis shows association rather than direction, both ALOX5-to-partner and partner-to-ALOX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDH24 grouped by ALOX5-low versus ALOX5-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALOX5→partner) and Y-score (partner→ALOX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CDH24 →	+4.584	+4.584	<.001	<.001	1	5
SOFT_TISSUE	FHOD3 →	+4.502	+5.066	.007	.007	1	5
STOMACH	APBA1 →	+3.942	+4.584	.002	.002	1	4
STOMACH	MYH11 →	+3.357	+4.285	.005	.005	1	4
STOMACH	ZNF365 →	+3.942	+4.584	.002	.002	1	4
STOMACH	TNKS1BP1 →	+2.942	+4.025	.009	.009	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,143 associations by consensus.

CDH24 by ALOX5 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →