ALOX12P2

Across TCGA patient cohorts, ALOX12P2 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALOX12P2-associated genes across cancer lineages are EGFR_pY1068, ACC1, and Ku80. Each is linked with ALOX12P2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALOX12P2-to-partner and partner-to-ALOX12P2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ALOX12P2-low versus ALOX12P2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALOX12P2→partner) and Y-score (partner→ALOX12P2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.307	-2.459	.011	.020	3	1
UCEC	ACC1 →	+0.439	+2.820	.012	.035	3	1
UCEC	Ku80 →	+0.299	+2.331	.008	.019	3	1
UCEC	p62 Lck ligand →	+0.587	+3.331	<.001	.005	3	1
UCEC	Shc_pY317 →	-0.294	-3.169	<.001	.019	3	1
UCEC	STAT3_pY705 →	-0.499	-2.459	<.001	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

EGFR_pY1068 by ALOX12P2 expression — UCEC

Explore this box plot interactively →