ALOX12P2

Across TCGA pan-cancer cohorts, ALOX12P2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ALOX12P2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ALOX12P2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ALOX12P2 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

HNSC, KIRC, and BLCA are the cancer types where ALOX12P2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ALOX12P2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.316	<.001	12	view →
KIRC	Female	IV	−0.670	<.001	12	view →
BLCA	All	III,IV	+1.358	<.001	10	view →
LUAD	All	All	+0.615	<.001	8	view →
LUSC	Male	II,III,IV	+1.195	<.001	7	view →
KICH	All	All	−0.662	<.001	7	view →
STAD	All	All	+0.454	.008	7	view →
BRCA	Female	All	−0.279	.006	4	view →
COAD	All	All	+0.265	.005	4	view →
THCA	All	All	+0.342	.007	2	view →
PRAD	All	All	−0.289	.013	2	view →
LIHC	All	All	+0.195	.043	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ALOX12P2–HNSC

Open the HNSC breakdown →