ALOX12P1

Across TCGA pan-cancer cohorts, ALOX12P1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated ALOX12P1 data layer.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher ALOX12P1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ALOX12P1 expression acts as an unfavorable survival marker, although some lineages such as PAAD and READ show a favorable association.

DLBC, PAAD, and READ are the cancer types where ALOX12P1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	OS	Quartile	All	0.207	1.000	<.001	78	view →
PAAD	OS	Tertile	All	0.722	0.357	.002	55	view →
READ	OS	Tertile	II,III,IV	0.808	0.448	.006	39	view →
BRCA	OS	Tertile	III,IV	0.801	0.407	<.001	36	view →
UCEC	DFS	Tertile	II,III,IV	0.603	0.760	.026	24	view →
MESO	OS	Tertile	IV	0.155	0.624	.004	20	view →
PRAD	DFS	Median	All	0.701	0.819	<.001	18	view →
SARC	OS	Tertile	All	0.382	0.568	.011	11	view →
SKCM	DFS	Tertile	All	0.678	0.590	.014	10	view →
THCA	OS	Quartile	IV	0.781	0.992	.019	9	view →
LGG	DFS	Median	All	0.797	0.860	.008	9	view →
PCPG	DFS	Tertile	All	0.653	0.915	.014	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

ALOX12P1–DLBC (OS)

Open the DLBC breakdown →