ALOX12B

Across TCGA patient cohorts, ALOX12B mutation is significantly associated with the RNA expression of many other genes, with 3,264 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALOX12B-associated genes across cancer lineages are C1orf174, SPTY2D1, and MAK16. Each is linked with ALOX12B in more than 3 cancer types. Because this analysis shows association rather than direction, both ALOX12B-to-partner and partner-to-ALOX12B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1orf174 grouped by ALOX12B-low versus ALOX12B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALOX12B→partner) and Y-score (partner→ALOX12B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C1orf174 →	+0.351	+2.706	<.001	<.001	3	4
UCEC	SPTY2D1 →	+0.364	+1.684	.003	.001	3	4
SKCM	MAK16 →	+0.564	+2.434	.005	.001	3	4
UCEC	HIRA →	+0.383	+3.202	<.001	<.001	3	4
UCEC	CDKN3 →	+0.577	+2.078	<.001	<.001	3	4
SKCM	KCTD9 →	+0.658	+2.919	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,264 associations by consensus.

C1orf174 by ALOX12B expression — UCEC

Explore this box plot interactively →