ALOX12B

Across TCGA pan-cancer cohorts, ALOX12B RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated ALOX12B data layer compared with 10 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ALOX12B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ALOX12B expression acts as an unfavorable survival marker, although some lineages such as KIRC and CESC show a favorable association.

UCEC, KIRC, and COAD are the cancer types where ALOX12B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.789	0.883	<.001	94	view →
KIRC	OS	Tertile	All	0.866	0.724	<.001	91	view →
COAD	DFS	Tertile	All	0.376	0.577	<.001	79	view →
CESC	OS	Median	III,IV	0.886	0.583	.001	64	view →
SKCM	OS	Tertile	All	0.276	0.409	<.001	57	view →
SCLC	OS	Median	All	0.818	0.581	.001	43	view →
LGG	DFS	Median	All	0.805	0.674	<.001	43	view →
UVM	DFS	Quartile	III,IV	0.992	0.463	.018	31	view →
LIHC	DFS	Tertile	III,IV	0.199	0.371	.017	28	view →
LUSC	OS	Quartile	II,III,IV	0.837	0.626	.003	9	view →
MESO	OS	Median	IV	0.770	0.358	.018	9	view →
THCA	DFS	Quartile	III,IV	0.777	0.919	.012	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

ALOX12B–UCEC (DFS)

Open the UCEC breakdown →