ALOX12B

Across TCGA cell cohorts, ALOX12B mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ALOX12B-associated genes across cancer lineages are ASPN, CNTN3, and HRK. Each is linked with ALOX12B in more than 1 cancer types. Because this analysis shows association rather than direction, both ALOX12B-to-partner and partner-to-ALOX12B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASPN grouped by ALOX12B-low versus ALOX12B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALOX12B→partner) and Y-score (partner→ALOX12B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ASPN →	+0.050	+3.600	<.001	.001	3	1
LARGE_INTESTINE	CNTN3 →	+0.325	+2.444	<.001	.008	3	1
LARGE_INTESTINE	HRK →	+0.553	+3.241	.003	.007	3	1
LARGE_INTESTINE	ECT2L →	+0.086	+3.478	<.001	.002	3	1
CNS	CLEC6A →	+0.029	+5.321	<.001	.005	3	1
SKIN	DIO3 →	+0.322	+4.064	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

ASPN by ALOX12B expression — LARGE_INTESTINE

Explore this box plot interactively →