ALOX12

Across TCGA pan-cancer cohorts, ALOX12 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ALOX12 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher ALOX12 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ALOX12 expression acts as an unfavorable survival marker, although some lineages such as GBM and HNSC show a favorable association.

GBM, HNSC, and UCEC are the cancer types where ALOX12 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Median	All	1.000	0.611	.003	6	view →
HNSC	OS	Median	II,III,IV	1.000	0.954	.027	5	view →
UCEC	OS	Median	II,III,IV	1.000	0.491	.038	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ALOX12–GBM (OS)

Open the GBM breakdown →