ALOX12

Across TCGA pan-cancer cohorts, ALOX12 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ALOX12’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ALOX12 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ALOX12 is over-expressed in tumor, although a few such as HNSC and KICH show the opposite, repressed pattern.

KIRC, KIRP, and HNSC are the cancer types where ALOX12 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ALOX12 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.558	<.001	11	view →
KIRP	Female	All	+0.773	<.001	9	view →
HNSC	All	All	−1.468	<.001	8	view →
KICH	Female	All	−0.778	<.001	7	view →
LIHC	Female	II,III,IV	+0.447	<.001	7	view →
UCEC	All	All	−0.612	<.001	6	view →
LUAD	Female	II,III,IV	−0.592	<.001	6	view →
BRCA	All	All	−0.317	<.001	6	view →
LUSC	Male	II,III,IV	+1.627	<.001	4	view →
CHOL	All	All	+1.515	<.001	3	view →
READ	All	All	−0.268	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ALOX12–KIRC

Open the KIRC breakdown →