ALOX12

Across TCGA patient cohorts, ALOX12 mutation is significantly associated with the RNA expression of many other genes, with 2,390 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALOX12-associated genes across cancer lineages are LINC02438, RN7SKP202, and TRGJP2. Each is linked with ALOX12 in more than 2 cancer types. Because this analysis shows association rather than direction, both ALOX12-to-partner and partner-to-ALOX12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02438 grouped by ALOX12-low versus ALOX12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALOX12→partner) and Y-score (partner→ALOX12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LINC02438 →	+0.625	+2.700	<.001	<.001	3	3
SARC	RN7SKP202 →	+0.392	+5.005	<.001	.009	3	2
UCEC	TRGJP2 →	+0.420	+1.666	<.001	.005	3	2
UCEC	MIR6075 →	+0.176	+1.921	.008	.004	3	2
BRCA	RNA5SP361 →	+0.257	+4.986	<.001	.003	3	2
BRCA	RNA5SP72 →	+0.256	+5.874	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,390 associations by consensus.

LINC02438 by ALOX12 expression — UCEC

Explore this box plot interactively →