ALOX12

Across TCGA cell cohorts, ALOX12 mutation is significantly associated with the drug of many other genes, with 44 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ALOX12-associated genes across cancer lineages are Nutlin-3a (-), AZD8055, and Niraparib. Each is linked with ALOX12 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALOX12-to-partner and partner-to-ALOX12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nutlin-3a (-) grouped by ALOX12-low versus ALOX12-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALOX12→partner) and Y-score (partner→ALOX12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Nutlin-3a (-) →	+0.910	+2.868	.007	.022	3	1
LARGE_INTESTINE	AZD8055 →	+0.540	+2.807	.025	.046	3	1
LARGE_INTESTINE	Niraparib →	+0.430	+2.868	.009	.022	3	1
LARGE_INTESTINE	Fulvestrant →	+0.344	+2.649	.038	.046	3	1
LARGE_INTESTINE	FGFR_3831 →	+0.515	+2.871	.042	.021	3	1
LARGE_INTESTINE	Luminespib →	+0.868	+2.868	.002	.022	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Nutlin-3a (-) by ALOX12 expression — LARGE_INTESTINE

Explore this box plot interactively →