ALMS1P1

Across TCGA patient cohorts, ALMS1P1 mutation is significantly associated with the immune_cell of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALMS1P1-associated genes across cancer lineages are cDC, Erythrocytes, and mv Endothelial cells. Each is linked with ALMS1P1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALMS1P1-to-partner and partner-to-ALMS1P1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, cDC grouped by ALMS1P1-low versus ALMS1P1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALMS1P1→partner) and Y-score (partner→ALMS1P1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	cDC →	+0.135	+3.010	.001	.019	3	1
UCEC	Erythrocytes →	+0.039	+2.241	.002	.031	3	1
UCEC	mv Endothelial cells →	-0.035	-3.311	.004	.010	3	1
UCEC	lymphatic Endothelial cells →	-0.025	-2.959	.041	.036	2	1
UCEC	Endothelial cells →	-0.051	-3.279	.011	.011	1	1
UCEC	pDC →	+0.085	+2.180	<.001	.036	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

cDC by ALMS1P1 expression — UCEC

Explore this box plot interactively →