ALMS1-IT1

Across TCGA pan-cancer cohorts, ALMS1-IT1 RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated ALMS1-IT1 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher ALMS1-IT1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ALMS1-IT1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and LGG show a favorable association.

KIRP, KIRC, and COAD are the cancer types where ALMS1-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	All	0.622	0.918	<.001	114	view →
KIRC	DFS	Tertile	All	0.514	0.690	<.001	111	view →
COAD	DFS	Median	All	0.412	0.649	<.001	98	view →
KICH	DFS	Median	II,III,IV	0.560	0.959	.001	95	view →
ACC	DFS	Median	All	0.414	0.746	<.001	80	view →
SKCM	OS	Tertile	All	0.834	0.718	<.001	60	view →
HNSC	OS	Tertile	All	0.262	0.451	<.001	55	view →
UCEC	DFS	Tertile	All	0.547	0.696	<.001	54	view →
MESO	OS	Quartile	All	0.295	0.608	.001	48	view →
PAAD	OS	Median	All	0.263	0.491	<.001	44	view →
LIHC	DFS	Quartile	All	0.408	0.605	<.001	33	view →
BRCA	DFS	Tertile	IV	0.272	0.842	.001	23	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

ALMS1-IT1–KIRP (OS)

Open the KIRP breakdown →