ALMS1-IT1

Across TCGA pan-cancer cohorts, ALMS1-IT1 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of ALMS1-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ALMS1-IT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ALMS1-IT1 is over-expressed in tumor.

HNSC, BLCA, and KIRC are the cancer types where ALMS1-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ALMS1-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	II,III,IV	+0.760	<.001	11	view →
BLCA	All	III,IV	+0.790	<.001	10	view →
KIRC	All	All	+0.162	<.001	10	view →
LUAD	Male	All	+0.850	<.001	9	view →
STAD	All	II,III,IV	+0.555	<.001	7	view →
COAD	All	All	+0.377	<.001	7	view →
LUSC	Male	II,III,IV	+0.969	<.001	5	view →
BRCA	All	II,III,IV	+0.271	.002	4	view →
LIHC	All	All	+0.156	.012	3	view →
PAAD	All	All	+0.830	.032	2	view →
CHOL	All	All	+0.554	.028	2	view →
KIRP	All	III,IV	+0.491	.024	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

ALMS1-IT1–HNSC

Open the HNSC breakdown →