ALKBH8

Across TCGA patient cohorts, ALKBH8 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,738 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible ALKBH8-associated proteins across cancer lineages are RNF214, MRE11, and MYO1C. Each is linked with ALKBH8 in more than 5 cancer types. Because this analysis shows association rather than direction, both ALKBH8-to-partner and partner-to-ALKBH8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ALKBH8 versus RNF214 in LSCC, with a Pearson correlation of 0.47.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ALKBH8→partner) and Y-score (partner→ALKBH8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RNF214 →	+0.252	+0.418	<.001	<.001	3	6
BRCA	MRE11 →	+0.331	+0.657	<.001	<.001	3	5
BRCA	MYO1C →	+0.422	+0.586	<.001	<.001	3	4
BRCA	CUL5 →	+0.243	+0.465	<.001	<.001	3	4
BRCA	EHD2_S438 →	+0.747	+0.572	<.001	<.001	3	4
OV	FAM76B_S193 →	+0.644	+0.595	<.001	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,738 associations by consensus.

ALKBH8 vs RNF214 — LSCC

Explore this scatter interactively →