ALKBH8

Across TCGA patient cohorts, ALKBH8 mutation is significantly associated with the RNA expression of many other genes, with 1,598 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALKBH8-associated genes across cancer lineages are MIR340, MIR367, and RNY4P14. Each is linked with ALKBH8 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALKBH8-to-partner and partner-to-ALKBH8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR340 grouped by ALKBH8-low versus ALKBH8-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALKBH8→partner) and Y-score (partner→ALKBH8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR340 →	+0.255	+3.839	<.001	.004	3	2
CESC	MIR367 →	+0.446	+3.966	.001	.001	3	2
CESC	RNY4P14 →	+0.199	+4.144	<.001	.009	3	2
CESC	MRPL32P1 →	+0.083	+4.569	<.001	.005	3	2
CESC	MIR1293 →	+0.321	+3.542	.004	.007	3	2
CESC	STAU2P1 →	+0.058	+3.779	.005	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,598 associations by consensus.

MIR340 by ALKBH8 expression — CESC

Explore this box plot interactively →