ALKBH7

Across TCGA cell cohorts, ALKBH7 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ALKBH7-associated genes across cancer lineages are IQCF5, TAS2R8, and CSN2. Each is linked with ALKBH7 in more than 2 cancer types. Because this analysis shows association rather than direction, both ALKBH7-to-partner and partner-to-ALKBH7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF5 grouped by ALKBH7-low versus ALKBH7-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALKBH7→partner) and Y-score (partner→ALKBH7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IQCF5 →	+0.124	+5.201	<.001	.006	3	3
LARGE_INTESTINE	TAS2R8 →	+0.042	+3.793	<.001	.007	3	1
LARGE_INTESTINE	CSN2 →	+0.033	+3.684	<.001	.006	3	1
LARGE_INTESTINE	DEFB134 →	+0.019	+3.684	<.001	.006	3	1
OVARY	RBMY1A1 →	+0.143	+5.807	<.001	.001	3	1
LUNG_NSCLC_LUAD	FIGLA →	+0.057	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

IQCF5 by ALKBH7 expression — BLOOD_Leukemia

Explore this box plot interactively →