ALKBH7

Across TCGA pan-cancer cohorts, ALKBH7 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated ALKBH7 data layer compared with 4 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ALKBH7 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ALKBH7 expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRP show a favorable association.

HNSC, KIRP, and BLCA are the cancer types where ALKBH7 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	III,IV	0.589	0.222	.001	50	view →
KIRP	OS	Median	III,IV	0.927	0.395	.004	37	view →
BLCA	DFS	Quartile	All	0.587	0.411	.001	34	view →
ACC	OS	Quartile	All	0.235	0.924	.004	28	view →
KICH	OS	Tertile	III,IV	0.212	0.913	.004	25	view →
PAAD	OS	Quartile	All	0.531	0.257	.001	24	view →
LIHC	OS	Quartile	II,III,IV	0.559	0.263	.003	15	view →
MESO	OS	Quartile	All	0.591	0.312	.008	13	view →
UCS	DFS	Quartile	III,IV	0.159	0.584	.003	12	view →
DLBC	DFS	Tertile	II,III,IV	0.984	0.134	.010	12	view →
READ	DFS	Median	All	0.779	0.439	.018	11	view →
LUSC	DFS	Tertile	II,III,IV	0.810	0.473	.006	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

ALKBH7–HNSC (OS)

Open the HNSC breakdown →