ALKBH6

Across TCGA patient cohorts, ALKBH6 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALKBH6-associated genes across cancer lineages are GSK-3a-b_pS21_S9, Akt_pT308, and Tuberin_pT1462. Each is linked with ALKBH6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALKBH6-to-partner and partner-to-ALKBH6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK-3a-b_pS21_S9 grouped by ALKBH6-low versus ALKBH6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALKBH6→partner) and Y-score (partner→ALKBH6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK-3a-b_pS21_S9 →	+0.558	+3.009	.023	.019	3	1
UCEC	Akt_pT308 →	+0.959	+3.000	.008	.037	3	1
UCEC	Tuberin_pT1462 →	+0.373	+2.817	.005	.036	3	1
UCEC	ATM →	-0.625	-3.000	.017	.037	3	1
UCEC	Caspase-7-cleavedD198 →	+0.823	+3.000	.016	.037	1	2
UCEC	14-3-3_beta →	-0.127	-2.986	.028	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

GSK-3a-b_pS21_S9 by ALKBH6 expression — UCEC

Explore this box plot interactively →