ALKBH6

Across TCGA pan-cancer cohorts, ALKBH6 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of ALKBH6’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where ALKBH6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ALKBH6 is over-expressed in tumor.

BLCA, COAD, and HNSC are the cancer types where ALKBH6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ALKBH6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Female	All	+1.082	<.001	11	view →
COAD	All	IV	+0.688	<.001	11	view →
HNSC	Male	IV	+0.606	<.001	11	view →
KIRC	Female	All	+0.404	<.001	11	view →
LIHC	Female	II,III,IV	+0.809	<.001	9	view →
KIRP	All	IV	+0.642	.004	8	view →
STAD	All	II,III,IV	+0.441	<.001	7	view →
LUSC	Male	II,III,IV	+0.804	<.001	6	view →
UCEC	All	III,IV	+0.453	.030	6	view →
BRCA	All	II,III,IV	+0.256	<.001	6	view →
CHOL	Male	All	+1.341	<.001	5	view →
LUAD	All	All	+0.322	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

ALKBH6–BLCA

Open the BLCA breakdown →