ALKBH4

Across TCGA pan-cancer cohorts, ALKBH4 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ALKBH4 data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ALKBH4 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ALKBH4 expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

UCEC, PDAC, and HNSC are the cancer types where ALKBH4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Quartile	All	0.791	0.977	.021	12	view →
PDAC	DFS	Tertile	III,IV	1.000	0.335	.008	10	view →
HNSC	DFS	Quartile	III,IV	0.593	0.941	.012	3	view →
LUAD	DFS	Median	III,IV	0.315	0.948	.008	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ALKBH4–UCEC (OS)

Open the UCEC breakdown →