ALKBH4

Across TCGA pan-cancer cohorts, ALKBH4 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of ALKBH4’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where ALKBH4 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types ALKBH4 is over-expressed in tumor, although a few such as PDAC and COAD show the opposite, repressed pattern.

PDAC, LSCC, and CCRCC are the cancer types where ALKBH4 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ALKBH4 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	All	All	−0.340	<.001	6	view →
LSCC	Male	II,III,IV	+0.175	<.001	6	view →
CCRCC	All	All	+0.103	<.001	3	view →
COAD	All	All	−0.189	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

ALKBH4–PDAC

Open the PDAC breakdown →