ALKBH1

Across TCGA patient cohorts, ALKBH1 mutation is significantly associated with the RNA expression of many other genes, with 1,195 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALKBH1-associated genes across cancer lineages are MIR8053, MIR549A, and RNU11-2P. Each is linked with ALKBH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALKBH1-to-partner and partner-to-ALKBH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR8053 grouped by ALKBH1-low versus ALKBH1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALKBH1→partner) and Y-score (partner→ALKBH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR8053 →	+0.379	+5.342	<.001	.002	3	2
CESC	MIR549A →	+0.336	+5.342	<.001	.002	3	2
BLCA	RNU11-2P →	+0.267	+3.878	.007	.002	3	2
UCEC	FAM177A1 →	+0.428	+2.233	.001	.006	3	2
UCEC	ZUP1 →	+0.462	+3.365	.006	.004	3	2
UCEC	SEC13 →	+0.413	+3.362	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,195 associations by consensus.

MIR8053 by ALKBH1 expression — CESC

Explore this box plot interactively →