Across TCGA patient cohorts, ALKAL2 mutation is significantly associated with the RNA expression of many other genes, with 722 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALKAL2-associated genes across cancer lineages are MRPL49, TMEM45B, and USP12. Each is linked with ALKAL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALKAL2-to-partner and partner-to-ALKAL2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALKAL2→partner) and Y-score (partner→ALKAL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRPL49 →	+0.678	+3.338	.002	.005	3	1
UCEC	TMEM45B →	+1.073	+3.459	.004	.005	3	1
UCEC	USP12 →	+0.561	+3.459	.009	.005	3	1
UCEC	SCOC →	+0.941	+3.364	<.001	.004	3	1
UCEC	DDAH1 →	+0.886	+3.480	.004	.002	3	1
UCEC	GABPA →	+0.667	+3.470	.007	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 722 associations by consensus.

Exploration

ALKAL2 survival (RNA) · tumor vs normal (RNA) · all ALKAL2 data types