ALK

Across TCGA patient cohorts, ALK mutation is significantly associated with the total protein of many other genes, with 95 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALK-associated genes across cancer lineages are Cyclin-B1, ASNS, and C-Raf. Each is linked with ALK in more than 3 cancer types. Because this analysis shows association rather than direction, both ALK-to-partner and partner-to-ALK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by ALK-low versus ALK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALK→partner) and Y-score (partner→ALK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.454	+1.874	.002	.002	3	4
COAD	ASNS →	+0.330	+1.700	.012	.040	3	4
COAD	C-Raf →	+0.161	+2.149	<.001	.008	3	4
UCEC	ACC1 →	+0.319	+2.150	<.001	<.001	3	4
LUAD	p90 RSK_pT359_S363 →	-0.211	-3.169	<.001	.018	3	3
COAD	Caspase-7-cleavedD198 →	+0.739	+1.856	.004	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 95 associations by consensus.

Cyclin-B1 by ALK expression — UCEC

Explore this box plot interactively →