ALK

Across TCGA pan-cancer cohorts, ALK RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ALK data layer compared with 5 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ALK RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ALK expression acts as an unfavorable survival marker, although some lineages such as PAAD and SKCM show a favorable association.

UCEC, STAD, and PAAD are the cancer types where ALK RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.510	0.758	<.001	76	view →
STAD	OS	Tertile	All	0.407	0.680	.001	54	view →
PAAD	DFS	Median	All	0.471	0.259	<.001	52	view →
BLCA	DFS	Quartile	All	0.235	0.457	<.001	49	view →
ACC	OS	Quartile	II,III,IV	0.680	0.920	.005	32	view →
UVM	OS	Tertile	All	0.413	0.779	.012	25	view →
HNSC	OS	Tertile	III,IV	0.492	0.797	.003	24	view →
LAML	DFS	Quartile	All	0.513	0.749	.010	24	view →
LUSC	DFS	Median	III,IV	0.227	0.801	.003	20	view →
SKCM	OS	Median	All	0.390	0.277	.001	20	view →
LIHC	OS	Quartile	All	0.423	0.706	.003	14	view →
BRCA	DFS	Quartile	II,III,IV	0.838	0.923	.001	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ALK–UCEC (DFS)

Open the UCEC breakdown →