ALK

Across TCGA cell cohorts, ALK RNA expression is significantly associated with the go_rna of many other GO terms, with 3,438 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ALK-associated GO terms across cancer lineages are RNA export from nucleus, Regulation of proteasomal protein catabolic process, and Regulation of mRNA splicing, via spliceosome. Each is linked with ALK in more than 9 cancer types. Because this analysis shows association rather than direction, both ALK-to-partner and partner-to-ALK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA export from nucleus grouped by ALK-low versus ALK-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ALK→partner) and Y-score (partner→ALK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	RNA export from nucleus →	+0.108	+0.180	<.001	.001	3	10
STOMACH	Regulation of proteasomal protein catabolic process →	+0.060	+0.208	<.001	.008	3	10
UPPER_AERODIGESTIVE_TRACT	Regulation of mRNA splicing, via spliceosome →	+0.102	+0.186	<.001	.001	3	9
STOMACH	Negative regulation of autophagy →	+0.107	+0.391	<.001	.005	3	9
LUNG_NSCLC_LUSC	Regulation of cytoplasmic translation →	+0.104	+0.305	<.001	.008	2	9
STOMACH	Regulatory ncRNA processing →	+0.089	+0.373	.001	.008	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,438 associations by consensus.

RNA export from nucleus by ALK expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →